When Adnexal Lymphoma Mimics Retinal Disease

A case highlights how mucosal lymphoma can initially be misdiagnosed as uveitis and chorioretinopathy, underscoring the need for broad diagnostic consideration.

By: Zack Oakey, MD

Retinal Physician April 1, 2026

Clinical Report: When Adnexal Lymphoma Mimics Retinal Disease

Overview

This report discusses a case where mucosal lymphoma was misdiagnosed as uveitis and chorioretinopathy, highlighting the importance of accurate diagnosis in ophthalmology. The case illustrates the need for awareness of adnexal lymphomas among retina specialists.

Background

Lymphoma can affect various parts of the body, including the eye, leading to diagnostic challenges due to its rarity. Misdiagnosis can result in inappropriate treatment and delayed care. Understanding the characteristics and presentation of adnexal lymphomas is crucial for timely and accurate diagnosis.

Data Highlights

No numerical data available in the article.

Key Findings

['Mucosal lymphomas can mimic uveitis and chorioretinopathy, complicating diagnosis.', 'Extranodal marginal zone lymphoma is the most common type affecting the eye.', 'Initial misdiagnosis can lead to inappropriate treatments, such as glucocorticoid therapy.', 'Histopathological examination is essential for accurate diagnosis of adnexal lymphomas.', 'Radiotherapy can restore normal retinal anatomy following treatment of adnexal lymphoma.']

Clinical Implications

Retina specialists should maintain a high index of suspicion for adnexal lymphomas in patients presenting with atypical retinal findings. Early referral for biopsy and appropriate imaging can facilitate accurate diagnosis and effective treatment.

Conclusion

Awareness of adnexal lymphomas and their presentations is vital for retina specialists to avoid misdiagnosis and ensure proper management of these conditions.

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Retinal Physician